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KMID : 0370220180620060374
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Yakhak Hoeji
2018 Volume.62 No. 6 p.374 ~ p.380
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Role of Transient Receptor Potential Melastatin(TRPM) Channels in the Stimulation of Melanin Synthesis by Diazoxide
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Lee Yong-Soo
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Abstract
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The known inhibitors of Ca2+-permeable transient receptor potential melastatin(TRPM) channels, flufenamic acid(FFA) and clotrimazole significantly blocked the diazoxide-induced increase in intracellular Ca2+ concentration([Ca2+]i) and melanin synthesis in B16 melanoma cells. H2O2 which has been shown to stimulate the activity of the TRPM channels, increased [Ca2+]i and melanin synthesis, which was significantly inhibited by FFA. These results suggest that TRPM channels may play an essential role in the diazoxide-induced melanogenesis through [Ca2+]i increase.
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KEYWORD
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diazoxide, melanogenesis, TRPM channel, Ca2+ signal, B16 melanoma cell
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